"Many of my patients are not cured by a combination of surgery, and chemotherapy and radiation therapy. When current standard therapy fails my patients, we have to look to new approaches and new ways to solve the problem of brain cancer."
Select Publications
J Neurooncol. 2019 Jul;143(3):417-428
Bmi1 regulates human glioblastoma stem cells through activation of differential gene networks in CD133+ brain tumor initiating cells.
Vora P, Seyfrid M, Venugopal C, Qazi MA, Salim S, Isserlin R, Subapanditha M, O'Farrell E, Mahendram S, Singh M, Bakhshinyan D, Chokshi C, McFarlane N, Dvorkin-Gheva A, Brown KR, Murty N, Moffat J, Bader GD, Singh SK.
Oncogene. 2019 Mar;38(10):1702-1716.
BMI1 is a therapeutic target in recurrent medulloblastoma.
Bakhshinyan D, Venugopal C, Adile AA, Garg N, Manoranjan B, Hallett R, Wang X, Mahendram S, Vora P, Vijayakumar T, Subapanditha M, Singh M, Kameda-Smith MM, Qazi M, McFarlane N, Mann A, Ajani OA, Yarascavitch B, Ramaswamy V, Farooq H, Morrissy S, Cao L, Sydorenko N, Baiazitov R, Du W, Sheedy J, Weetall M, Moon YC, Lee CS, Kwiecien JM, Delaney KH, Doble B, Cho YJ, Mitra S, Kaplan D, Taylor MD, Davis TW, Singh SK.
Cancer Res. 2018 Sep 1;78(17):5124-5134.
Therapeutic Targeting of the Premetastatic Stage in Human Lung-to-Brain Metastasis.
Singh M, Venugopal C, Tokar T, McFarlane N, Subapanditha MK, Qazi M, Bakhshinyan D, Vora P, Murty NK, Jurisica I, Singh SK.
Cancer Res. 2018 Sep 1;78(17):5023-5037.
Cotargeting Ephrin Receptor Tyrosine Kinases A2 and A3 in Cancer Stem Cells Reduces Growth of Recurrent Glioblastoma.
Qazi MA, Vora P, Venugopal C, Adams J, Singh M, Hu A, Gorelik M, Subapanditha MK, Savage N, Yang J, Chokshi C, London M, Gont A, Bobrowski D, Grinshtein N, Brown KR, Murty NK, Nilvebrant J, Kaplan D, Moffat J, Sidhu S, Singh SK.
Front Oncol. 2017 Sep 19;7:220.
Preclinical Modeling and Therapeutic Avenues for Cancer Metastasis to the Central Nervous System.
Singh M, Bakhshinyan D, Venugopal C, Singh SK.
Acta Neuropathol. 2017 Dec;134(6):923-940.
RNAi screen identifies essential regulators of human brain metastasis-initiating cells.
Singh M, Venugopal C, Tokar T, Brown KR, McFarlane N, Bakhshinyan D, Vijayakumar T, Manoranjan B, Mahendram S, Vora P, Qazi M, Dhillon M, Tong A, Durrer K, Murty N, Hallet R, Hassell JA, Kaplan DR, Cutz JC, Jurisica I, Moffat J, Singh SK.
J Neurooncol. 2016 Jan;126(1):57-67.
A novel stem cell culture model of recurrent glioblastoma.
Qazi MA, Vora P, Venugopal C, McFarlane N, Subapanditha MK, Murty NK, Hassell JA, Hallett RM, Singh SK.
Clinical Cancer Research. 2015 Dec 1;21(23):5324-37.
Pyrvinium Targets CD133 in Human Glioblastoma Brain Tumor-Initiating Cells.
Venugopal C, Hallett R, Vora P, Manoranjan B, Mahendram S, Qazi MA, McFarlane N, Subapanditha M, Nolte SM, Singh M, Bakhshinyan D, Garg N, Vijayakumar T, Lach B, Provias JP, Reddy K, Murty NK, Doble BW, Bhatia M, Hassell JA, Singh SK.
Journal of the National Cancer Institute. 2013 Apr 17;105(8):551-62.
A cancer stem cell model for studying brain metastases from primary lung cancer.
Nolte SM, Venugopal C, McFarlane N, Morozova O, Hallett RM, O'Farrell E, Manoranjan B, Murty NK, Klurfan P, Kachur E, Provias JP, Farrokhyar F, Hassell JA, Marra M, Singh SK.
Nature. 2004 Nov 18;432(7015):396-401.
Identification of human brain tumour initiating cells.
Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, Hide T, Henkelman RM, Cusimano MD, Dirks PB.
Cancer Res. 2003 Sep 15;63(18):5821-8.
Identification of a cancer stem cell in human brain tumors.
Singh SK, Clarke ID, Terasaki M, Bonn VE, Hawkins C, Squire J, Dirks PB.
Dr. Sheila Singh | Pediatric Neurosurgeon, McMaster Children’s Hospital | Principal Investigator, McMaster Cancer Research Centre
Michael G. DeGroote Centre for Learning and Discovery, Room 5029 | McMaster University | 1280 Main Street West | Hamilton, Ontario L8S4K1