These are the passionate and dedicated individuals that are the face, the heart, the brain, and the soul of the Sheila Singh Lab. They work tirelessly, inspired by the lives of patients. And, together, their efforts are expanding the frontiers of brain cancer research.

Sheila Singh, Sheila Singh Lab

Sheila Singh, MD, PhD, FRCSC

Principal Investigator

Clinician Scientist.

Chitra Venugopal, Sheila Singh Lab

Chitra Venugopal, PHD

Senior Research Associate

Responsible for planning, managing, and overseeing multiple research programs.

Mathieu Seyfrid, Sheila Singh Lab

Mathieu Seyfrid, PHD

Post Doctoral Fellow

Elucidation of glioblastoma aggressiveness directly on cells and through their supportive environment, with chimeric antigen receptor (CAR) T-cells.

Blessing Bassey-Archibong, Sheila Singh Lab

Blessing Bassey-Archibong, PHD

Post Doctoral Fellow

Identification of inherent molecular factors that drive brain metastasis.

Sheila Singh Lab, Deepak Upreti

Deepak Upreti, PHD

Post Doctoral Fellow

Development and generation of next generation CD133-based chimeric antigen receptor (CAR) T-cell for glioblastoma.

Fred Lam, MD, PHD, FRCSC

Clinical Scholar

 

William Gwynne, PHD

PostDoctoral Fellow

 

Sheila Singh Lab, Chirayu Chokshi

Chirayu Chokshi, HBSc

PHD Candidate

Elucidation of synthetic and post-treatment vulnerabilities in glioblastoma through CRISPR-Cas9 based functional genomic platform.

Sheila Singh Lab, Nazanin Tatari

Nazanin Tatari, Msc

PHD Candidate

Identification, validation and therapeutic targeting of novel tumor associated antigens for treatment-refractory glioblastoma.

Stefan Custers, MSc

PhD Candidate

 

Sheila Singh Lab, Ashley Adile

Ashley Adile, HBSc

MSc Candidate

Identification of potent FDA-approved chemical compounds that specifically target recurrent medulloblastoma spinal metastases.

Sheila Singh Lab, Neil Savage

Neil Savage, HBSc

MSc Candidate

Investigation of novel stem cell markers for treatment of primary and recurrent glioblastoma.

Sheila Singh Lab, Agata Kieliszek

Agata Kieliszek, HBSc

MSc Candidate

Identification of novel drug candidates that target and effectively inhibit brain metastases derived from lung, breast and melanoma primary tumours.

Sheila Singh Lab, Sabra Salim

Sabra Salim, HBSc

MSc Candidate

Assessment and optimization of a CD133-specific chimeric antigen receptor (CAR) T-cell for glioblastoma.

Sheila Singh Lab, Nikoo Aghaei

Nikoo Aghaei, HBSc

MSc Candidate

Exploration the Wnt signalling pathway and its aberrant functioning in brain metastasis to develop targeted therapies for cancer patients.

William Maich, HBSc

MSc Candidate

 

Sheila Singh Lab, Dillon McKenna

Dillon McKenna, MSc

Laboratory Technician

Animal research technician.

Alumni
Sheila Singh Lab, Emily Ford

Emily Ford

2019 Alumnus

Undergraduate Researcher. Investigated new strategies to target brain metastases by 'retraining' the immune system to recognize and kill cancer cells.

Sheila Singh Lab, Michelle Kameda-Smith

Michelle Kameda-Smith, MD, PHD

2019 Alumnus

Doctoral Candidate. Investigated the role of Musashi 1 in Group 3 medulloblastoma.

David Bakhshinyan, Sheila Singh Lab

David Bakhshinyan, PHD

2019 Alumnus

Doctoral Candidate. Characterized the molecular mechanisms underlying tumour recurrence in pediatric medulloblastoma by developing therapy adapted patient-derived xenograft models to uncover novel targeted therapies for patients who are largely limited to palliation.

Sheila Singh Lab, Maleeha Qazi

Maleeha Qazi, PHD

2019 Alumnus

Doctoral Candidate. Studied the treatment resistance and evolution of glioblastoma over the course of therapy with development of a pre-clinical, therapy-adapted model of tumour recurrence to identify personalized targets for therapeutic development.

Branavan Manoranjan, PHD

2019 Alumnus

MD-Phd Candidate. Characterized intrinsic differences in the tumour-initiating capacity of Wnt and non-Wnt medulloblastomas with aims to discover whether Wnt activation in non-Wnt tumour could serve as a rationale for therapy for patients.

Nicolas Yelle, HBSc

2018 Alumnus

Master’s Candidate. Studied the role of DKK1 as a novel candidate therapeutic target for recurrent glioblastoma.

Mohini Singh, PHD

2018 Alumnus

Doctoral Candidate. Elucidated drivers of brain metastasis

Minomi K Subapanditha, HBSc

2018 Alumnus

Laboratory Technician.

Parvez Vora, Sheila Singh Lab

Parvez Vora, PHD

2018 Alumnus

Post-Doctoral Fellow. Conducted preclinical validation studies of novel immunotherapies to target treatment-refractory glioblastoma cell population.

Dr. Sheila Singh  |  Pediatric Neurosurgeon, McMaster Children’s Hospital  |  Principal Investigator, McMaster Stem Cell and Cancer Research Institute

Michael G. DeGroote Centre for Learning and Discovery, Room 5027  |  McMaster University  |  1280 Main Street West  |  Hamilton, Ontario L8S4K1

Alumni

Dr. Sheila Singh  |  Pediatric Neurosurgeon, McMaster Children’s Hospital  |  Principal Investigator, McMaster Stem Cell and Cancer Research Institute  |  Michael G. DeGroote Centre for Learning and Discovery, Room 5027  |  McMaster University  |  1280 Main Street West  |  Hamilton, Ontario L8S4K1

Alumni

Dr. Sheila Singh  |  Pediatric Neurosurgeon, McMaster Children’s Hospital  |  Principal Investigator, McMaster Stem Cell and Cancer Research Institute  |  MDCL, rm 5027  |  McMaster University  |  1280 Main Street West  |  Hamilton, Ontario L8S4K1